Myotonic Dystrophy Type 2 Myotonic Dystrophy Type 2 (DM2) is a rare, genetic, multi-system neuromuscular disorder. It is characterized by progressive muscle weakness, prolonged muscle contractions (myotonia), and chronic muscle pain. Unlike Type 1 (DM1), which primarily impacts the distal muscles (like hands and feet), DM2 targets the proximal muscles closest to the center of the body, such as the hips, thighs, shoulders, and neck flexors. Because its onset is subtle and symptoms mimic other common conditions, it frequently goes undiagnosed or misdiagnosed for years. Symptoms and Clinical Presentation
Symptoms of DM2 typically surface during adulthood, most commonly between a person’s 20s and 40s. The severity and progression vary widely, even among biological relatives. How myotonic dystrophy type 2 (DM2) is inherited
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